Thermolabile 5,10-MethylenetetrahydrofoIate Reductase as a Cause of Mild Hyperhomocysteinemia
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Thermolabile 5,10-methylenetetrahydrofolate reductase as a cause of mild hyperhomocysteinemia.
Thermolability of 5,10-methylenetetrahydrofolate reductase (MTHFR) was examined as a possible cause of mild hyperhomocysteinemia in patients with premature vascular disease. Control subjects and vascular patients with mild hyperhomocysteinemia and with normohomocysteinemia were studied. The mean (+/- SD) specific MTHFR activity in lymphocytes of 22 control subjects was 15.6 (+/- 4.7) nmol CH2O/...
متن کاملGenetic analysis of the thermolabile variant of 5, 10-methylenetetrahydrofolate reductase as a risk factor for ischemic stroke.
Mild hyperhomocysteinemia is a risk factor for atherosclerotic vascular disease. Homozygosity for the C677T mutation in the gene for 5,10-methylenetetrahydrofolate reductase (MTHFR) is frequently associated with hyperhomocysteinemia, particularly in individuals with low levels of serum folate, and has been directly associated with cardiovascular disease in certain populations. The purpose of th...
متن کاملEffect of multivitamins on plasma homocysteine in patients with the 5,10 methylenetetrahydrofolate reductase C677T homozygous state.
The role of hyperhomocysteinemia (HHcy) as a cardiovascular risk factor remains a matter of debate, while it correlates with folates, it demonstrates inverse correlation with plasma homocysteine (Hcy) levels and vitamin B12 levels and reduces plasma Hcy levels following supplementation with multivitamins. The purpose of this study was to demonstrate that administering multivitamins at specific ...
متن کاملand motor function . preserves
Oxidative damage has been suggested as a potential mechanism for both atherosclerosis and neurodegenerative disorders such as Parkinson's disease.' One report has noted a 2-5-fold increased risk of cardiovascular disease among patients with Parkinson's disease,2 suggesting that a common genetic variant may contribute to both diseases. One such candidate genetic factor, the ApoE-E4 allele, is fo...
متن کاملand motor function . preserves sensory
Oxidative damage has been suggested as a potential mechanism for both atherosclerosis and neurodegenerative disorders such as Parkinson's disease.' One report has noted a 2-5-fold increased risk of cardiovascular disease among patients with Parkinson's disease,2 suggesting that a common genetic variant may contribute to both diseases. One such candidate genetic factor, the ApoE-E4 allele, is fo...
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تاریخ انتشار 2017